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专利名称：ASYMMETRIC HYDROFORMYLATIONS OF
PROCHIRAL OLEFINS TO CHIRALALDEHYDES IN HIGH ENANTIOMERICEXCESS.
发明人：STILLE, JOHN, K.,PARRINELLO, GIOVANNI申请号：EP804854申请日：19880505公开号：EP0314759A4公开日：19900129
摘要：Asymmetric hydroformylations of chiral olefins can be achieved by contacting,under hydroformylation conditions, an olefin containing a prochiral center with hydrogenand carbon monoxide in the presence of a catalyst comprising a complex of platinum IIand N-(t-butoxycarbonyl)-(2S, 4S)-4-(diphenylphosphino)-2-[(diphenylphosphino)methyl]pyrrolidine and stannous chloride, and removing the resulting chiral aldehyde as it isformed. A preferred method of removing the resulting chiral aldehyde is through the useof a trapping agent such as triethyl orthoformate, trimethyl orthoformate, triethylorthoacetate, trimethyl orthoacetate, acetone diethyl ketal and acetone dimethyl acetalused in the presence of a solid catalyst support such as cross-linked polystyrene.
申请人：COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
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