CAS No.
50-00-0Formaldehyde50-06-650-07-750-18-0
6055-19-250-29-3
PhenobarbitalMitomycin CCyclophosphamide
DDT (4,4'-Dichlorodiphenyltrichloroethane)
Agent
Group12B2B12A13333333332B2A2A313332A3332A
VolumeSup 7, 62, 88, 100FSup 7, 7910, Sup 726, Sup 7, 100A
Sup 7, 53, 113Sup 7, 92, 100F13, Sup 721, Sup 726, Sup 724, Sup 710, Sup 713, Sup 730, Sup 79, Sup 726, Sup 7Sup 7, 799, Sup 77, Sup 7, 96Sup 7, 79Sup 7, 50, 100A9, Sup 730, Sup 726, Sup 7Sup 7, 9213, Sup 750
4, Sup 717, Sup 7
Year2012200119872012In prep.20121987198719871987198719871987198719872001198720102001201219871987198720101987199019871987
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data
Additional information
50-32-8Benzo[a]pyrene50-33-950-41-950-44-250-55-550-76-051-02-551-03-6PhenylbutazoneClomiphene citrate6-MercaptopurineReserpine
Actinomycin D
Pronetalol hydrochloridePiperonyl butoxide51-18-32,4,6-Tris(1-aziridinyl)-s-triazine51-21-851-52-551-75-251-79-652-01-7
5-FluorouracilPropylthiouracilNitrogen mustard
Ethyl carbamate (Urethane)Spironolactone
52-24-4Thiotepa52-46-0Apholate52-68-6Trichlorfon53-03-2Prednisone53-70-3Dibenz[a,h]anthracene54-05-7Chloroquine54-31-9Furosemide (Frusemide)
54-85-3Isonicotinic acid hydrazide (Isoniazid)55-18-5N-Nitrosodiethylamine
55-98-11,4-Butanediol dimethanesulfonate (see Busulfan)55-98-1Busulfan55-98-156-04-256-23-556-25-756-38-2
Myleran (see Busulfan)MethylthiouracilCarbon tetrachlorideCantharidinParathion
12B2B32B12B2A32B32B2B32B333312B332B2B2B2B332B312B32B3
4, Sup 7, 100ASup 7, 7920, Sup 7, 7110, Sup 7
30, Sup 7, 11221, Sup 7, 100A92, Sup 7Sup 7, 5073, Sup 74, Sup 7, 719, Sup 7Sup 7, 6, Sup 7, 7179
Sup 7, 53, 7931, Sup 751
13, Sup 75111350, 10826, Sup 750
17, Sup 78, Sup 78, Sup 77, Sup 7, 7179
5, Sup 713, Sup 779, Sup 724, Sup 7, 100A7, Sup 727, Sup 77, Sup 7Sup 7, 79
2012200119991987In prep.20122010199019991999198719961999200120011987199119871991In prep.2016198719901987198719871999200119871987200120121987198719872001
NB: Overall evaluation downgraded to Group 3 with supporting evidence from other relevant data
NB: Overall evaluation downgraded to Group 3 with supporting evidence from other relevant data
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
56-53-1Diethylstilbestrol
56-55-3Benz[a]anthracene56-75-7Chloramphenicol57-06-757-14-757-39-657-41-057-57-8
Allyl isothiocyanate1,1-DimethylhydrazineTris(2-methyl-1-aziridinyl)phosphine oxidePhenytoin
beta-Propiolactone
57-68-1Sulfamethazine57-74-957-88-558-08-258-14-058-55-958--958-93-559-05-259-87-059--260-09-360-11-760-35-560-56-060-57-161-57-4
ChlordaneCholesterolCaffeine
PyrimethamineTheophylline
Lindane (see also Hexachlorocyclohexanes)HydrochlorothiazideMethotrexate
Nitrofural (Nitrofurazone)N-Nitrosomorpholinepara-Aminoazobenzene
para-DimethylaminoazobenzeneAcetamideMethimazoleDieldrinNiridazole
61-82-5Amitrole62-44-2Phenacetin62-50-062-53-362-55-562-56-6
Ethyl methanesulfonateAnilineThioacetamideThiourea
Agents Classified by the IARC Monographs, Volumes 1–116
CAS No.
62-73-7Dichlorvos62-75-9N-Nitrosodimethylamine63-25-2Carbaryl63-92-3Phenoxybenzamine hydrochloride-17-5Ethanol in alcoholic beverages-67-5Diethyl sulfate
Agent
Group2B2A32B12A
VolumeSup 7, 5317, Sup 712, Sup 724, Sup 796, 100E54, 71
Year199119871987198720121999
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
Additional information
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
66-27-3Methyl methanesulfonate66-75-167-20-967-45-867-63-067-66-367-72-168-12-268-76-869-53-4
Uracil mustardNitrofurantoinFurazolidoneIsopropyl alcoholChloroform
HexachloroethaneDimethylformamide
Tris(aziridinyl)-para-benzoquinone (Triaziquone)Ampicillin
2A2B3332B2B2A332A3132B332B3333331
7, Sup 7, 719, Sup 750
31, Sup 715, Sup 7, 71Sup 7, 7373
47, 71, 1159, Sup 7504, Sup 720, Sup 729, Sup 7. 100F
20, Sup 7, 7121, Sup 75, Sup 720, Sup 78, Sup 7
41, Sup 7, 71Sup 7, 6041, Sup 7, 7141, Sup 7, 7152, 7152, 71Sup 7, 97, 100F
1999198719901987199919991999In prep.19871990198719872012199919871987198719871999199419991999199919992012
70-25-7N-Methyl-N´-nitro-N-nitrosoguanidine (MNNG)70-30-4Hexachlorophene71-43-2Benzene71-55-671-58-972-20-872-43-572-57-174-83-974-85-174-87-374-88-474-96-475-00-3
1,1,1-Trichloroethane
Medroxyprogesterone acetateEndrin
MethoxychlorTrypan blueMethyl bromideEthylene
Methyl chlorideMethyl iodideBromoethaneChloroethane
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
75-01-4Vinyl chloride
75-02-5Vinyl fluoride2ASup 7, 63, 972008
NB: (1) Overall evaluation upgraded to Group 2A based on mechanistic and other relevant data;
(2) For practical purposes, vinyl fluoride should be considered to act similarly to the human carcinogen vinyl chloride
75-07-0Acetaldehyde
75-07-0Acetaldehyde associated with consumption of alcoholic beverages75-09-2Dichloromethane (Methylene chloride)75-21-8Ethylene oxide75-25-275-27-475-35-475-38-775-45-675-52-575-55-875-56-975-60-575-87-675-88-776-01-776-03-976-44-877-09-8
BromoformBromodichloromethaneVinylidene chlorideVinylidene fluorideChlorodifluoromethaneNitromethane
2-Methylaziridine (Propyleneimine)Propylene oxideDimethylarsinic acidChloral
2-Chloro-1,1,1-trifluoroethanePentachloroethaneTrichloroacetic acidHeptachlor
Phenolphthalein
2B12A132B3332B2B2B2B2A332B2B2B2A2B13312A32B2B
36, Sup 7, 71100E
Sup 7, 71, 110Sup 7, 60, 97, 100F52, 7152, 71
39, Sup 7, 7139, Sup 7, 7141, Sup 7, 7177
9, Sup 7, 71Sup 7, 60100C63, 84, 101, Sup 7, 7141, Sup 7, 7163, 84, 106Sup 7, 53, 797, Sup 7, 7160, 71
41, Sup 7, 71, 1105152, 71
Sup 7, 63, 10660, Sup 719, Sup 7, 7120, Sup 7, 71, 106
63, 84, 106
19992012In prep.201219991999199919991999200019991994201220141999199920142001200019991999In prep.1991199920141994199920142014
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data
77-78-1Dimethyl sulfate78-79-5Isoprene
78-87-51,2-Dichloropropane78-98-8Methylglyoxal79-00-51,1,2-Trichloroethane79-01-6Trichloroethylene79-06-1Acrylamide79-10-7Acrylic acid
79-34-51,1,2,2-Tetrachloroethane79-43-6Dichloroacetic acid
Agents Classified by the IARC Monographs, Volumes 1–116
CAS No.
79-44-7Dimethylcarbamoyl chloride79-46-92-Nitropropane79-94-7Tetrabromobisphenol A80-08-0Dapsone80-62-6Methyl methacrylate81-07-2Saccharin and its salts81-15-281-49-281-88-982-28-082-68-8
Musk xylene
1-Amino-2,4-dibromoanthraquinoneRhodamine B
1-Amino-2-methylanthraquinoneQuintozene (Pentachloronitrobenzene)
Agent
Group2A2B2A33332B33333332B3333333332B332B3332A
Volume12, Sup 7, 7129, Sup 7, 7111524, Sup 7Sup 7, 60Sup 7, 7365101
16, Sup 727, Sup 75, Sup 7928, Sup 76551101
Sup 7, 92Sup 7, 738, Sup 78, Sup 78, Sup 727, Sup 724, Sup 746
Sup 7, 92
32, Sup 7, 71, 103
30, Sup 7Sup 7, 77577353, 7127, Sup 719, Sup 7, 71101
Year19991999In prep.19871994199919962013198719871987201019871996199120132010199919871987198719871987192010201319872000199319991999198719992013
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
NB: Overall evaluation downgraded to Group 3 with supporting evidence from other relevant data
Additional information
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
83-32-9Acenaphthene
83-63-6Diacetylaminoazotoluene83-66-983-67-084-65-185-01-885-68-785-83-685-84-785-86-986-30-686-54-486-57-786-73-7
Musk ambretteTheobromineAnthraquinonePhenanthreneButyl benzyl phthalateScarlet RedYellow ABSudan IIIN-NitrosodiphenylamineHydralazine
1-NitronaphthaleneFluorene
86-74-8Carbazole86-88-487-29-687-62-787-68-387-86-588-05-188-12-01-Naphthylthiourea (ANTU)Cinnamyl anthranilate
2,6-Dimethylaniline (2,6-Xylidine)Hexachlorobutadiene
Pentachlorophenol (see Polychlorophenols)2,4,6-Trimethylaniline
N-Vinyl-2-pyrrolidone88-72-22-Nitrotoluene88-73-3
121-73-3
100-00-5-82-790-04-090-43-790-65-390-94-1-20-391-23-6
Chloronitrobenzenes
Pulegone
ortho-Anisidineortho-PhenylphenolPenicillic acid
Michler’s ketone [4,4´-Bis(dimethylamino)-benzophenone]Naphthalene2-Nitroanisole
32B2B332B2B2B1332B1132B32B2B2B2B3132A3332B2B2A2B2B
65
108
Sup 7, 7373
10, Sup 7998265
4, Sup 7, 99, 100FSup 7, 7739, Sup 729, Sup 71, Sup 7, 99, 100F
29, Sup 7, 99, 100F4, Sup 7101
36, Sup 7, 7110, Sup 710, Sup 7113
30, Sup 7Sup 7, 73Sup 7, 77, 99, 100F16, Sup 777, 9916, Sup 716, Sup 777, 9916, Sup 727, Sup 7Sup 7, 6020, Sup 7, 7177
1996201619991999198720102002199620122000198719872012201219872013199919871987In prep.1987199920121987201019871987201019871987199419992000
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
91-59-82-Naphthylamine
91--5Coumarin
91-93-03,3'-Dimethoxybenzidine-4,4'-diisocyanate91-94-13,3'-Dichlorobenzidine92-67-14-Aminobiphenyl92-87-5Benzidine92-93-393-15-294-36-094-58-694-59-794-75-795-06-795-50-1
4-NitrobiphenylMethyleugenolBenzoyl peroxideDihydrosafroleSafrole
2,4-D (2,4-dichlorophenoxyacetic acid) (See also Chlorophenoxy herbicides)Sulfallateortho-Dichlorobenzene
95-53-4ortho-Toluidine95-68-195-69-295-70-595-78-395-79-495-80-795-83-0
2,4-Xylidine4-Chloro-ortho-toluidine2,5-Diaminotoluene2,5-Xylidine
5-Chloro-ortho-toluidine2,4-Diaminotoluene
4-Chloro-ortho-phenylenediamine
96-09-3Styrene-7,8-oxide
96-12-81,2-Dibromo-3-chloropropane96-13-92,3-Dibromopropan-1-ol
Agents Classified by the IARC Monographs, Volumes 1–116
CAS No.
96-18-41,2,3-Trichloropropane96-23-11,3-Dichloro-2-propanol
96-24-23-Monochloro-1,2-propanediol
96-33-3Methyl acrylate
Agent
Group2A2B2B3
Volume6310110139, Sup 7, 71
Year1995201320131999
NB: Overall evaluation downgraded to Group 3 with supporting evidence from other relevant data
Additional information
96-45-7Ethylenethiourea96-48-097-53-097-56-397-77-8-01-198-82-8-83-998-87-3
98-07-7
100-44-7
98-88-498-95-399-08-1
99-99-099-55-9-56-999-57-099-59-299-80-999-97-8100-40-3100-41-4100-42-5100-75-4
gamma-ButyrolactoneEugenol
ortho-AminoazotolueneDisulfiramFurfuralCumene
a-Methylstyrene
alpha-Chlorinated toluenes (benzal chloride, benzotrichloride, benzyl chloride) and benzoyl chloride (combined exposures)NitrobenzeneNitrotoluenes
5-Nitro-ortho-toluidine1,2-Diamino-4-nitrobenzene2-Amino-4-nitrophenol
5-Nitro-ortho-anisidineN-Methyl-N,4-dinitrosoanilineDimethyl-p-toluidine4-VinylcyclohexeneEthylbenzeneStyrene
N-Nitrosopiperidine
3332B332B2B2A2B3333332B2B2B2B2B1332B32B2B2B3333333333432B2B332B2B
Sup 7, 7911, Sup 7, 7136, Sup 78, Sup 712, Sup 76310110129, Sup 7, 716565
20011999198719871987199520132013199919961996
101-14-44,4'-Methylenebis(2-chloroaniline) (MOCA)101-21-3101-25-7101-61-1101-68-8101-77-9101-80-4101-90-6102-50-1102-71-6103-03-7103-11-7103-23-1103-33-3103-90-2103-90-2104-94-9105-11-3105-55-5105-60-2105-74-8106-46-7106-47-8106-50-3106-51-4106-87-6
Chloropropham
DinitrosopentamethylenetetramineMichler’s base [4,4´-methylenebis(N,N-dimethyl)-benzenamine]4,4'-Methylenediphenyl diisocyanate4,4'-Methylenedianiline4,4'-Diaminodiphenyl etherDiglycidyl resorcinol ethermeta-CresidineTriethanolaminePhenicarbazide
2-Ethylhexyl acrylateDi(2-ethylhexyl) adipateAzobenzene
Acetaminophen (see Paracetamol)Paracetamol (Acetaminophen)para-Anisidinepara-Benzoquinone dioximeN,N'-DiethylthioureaCaprolactamLauroyl peroxidepara-Dichlorobenzenepara-Chloroanilinepara-Phenylenediaminepara-Quinone4-Vinylcyclohexene diepoxide
48199016, Sup 7198757199327, Sup 719871, Sup 71987
115 In prep.Sup 7, 60199477200060, 82200217, Sup 71987
NB: Overall evaluation upgraded to
Sup 7, 57, 99,
2012Group 1 based on mechanistic and other
100F
relevant data
12, Sup 7198711, Sup 7198727, Sup 7, 99201019, Sup 7, 71199939, Sup 7198729, Sup 7198736, Sup 7, 71199927, Sup 7198777200012, Sup 71987601994Sup 7, 7720008, Sup 7198750, 7327, Sup 729, Sup 7, 7179
39, Sup 7, 7136, Sup 7, 71Sup 7, 7357
16, Sup 715, Sup 7, 71Sup 7, 6047, 71
199919871999200119991999199919931987199919941999
NB: Overall evaluation upgraded to Group 2B with supporting evidence from other relevant data
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
106-88-71,2-Epoxybutane
106--8Epichlorohydrin2A11, Sup 7, 711999
106-93-4Ethylene dibromide106-94-51-Bromopropane106-99-01,3-Butadiene107-02-8107-05-1107-06-2107-13-1107-14-2
Acrolein
Allyl chloride
1,2-DichloroethaneAcrylonitrileChloroacetonitrile
2A2B1332B2B3
15, Sup 7, 71115
Sup 7, 54, 71, 97, 100F63, Sup 736, Sup 7, 7120, Sup 7, 717152, 71
1999In prep.201219951999199919991999
107-30-2Chloromethyl methyl ether (see Bis(chloromethyl)ether; chloromethyl methyl ether)108-05-4108-10-1108-30-5108-45-2
Vinyl acetateMethyl isobutyl ketoneSuccinic anhydride
meta-Phenylenediamine
2B2B33
Sup 7, 63101
15, Sup 716, Sup 7
1995201319871987
Agents Classified by the IARC Monographs, Volumes 1–116
CAS No.
108-46-3Resorcinol
108-60-1Bis(2-chloro-1-methylethyl)ether108-78-1Melamine108-88-3108-94-1108-95-2110-00-9110-57-6110-86-1110-91-8111-42-2111-44-4111-76-2115-02-6115-07-1115-28-6115-32-2115-96-8116-06-3
Toluene
CyclohexanonePhenolFuran
trans-1,4-DichlorobutenePyridineMorpholineDiethanolamine
Bis(2-chloroethyl)ether2-ButoxyethanolAzaserinePropylene
Chlorendic acidDicofol
Tris(2-chloroethyl) phosphateAldicarb
Agent
Group3333332B3332B332B32B333
Volume15, Sup 7, 7141, Sup 7, 71Sup 7, 7347, 7147, 7147, 7163
15, Sup 7, 717747, 7177, 1019, Sup 7, 7188
10, Sup 7Sup 7, 6048
30, Sup 748, 7153
19, Sup 7, 71, 11050
Sup 7, 7327, Sup 7Sup 7, 77, 101Sup 7, 7916, Sup 765
16, Sup 71014, Sup 71, Sup 792, Sup 710, Sup 727, Sup 715, Sup 7, 7165
31, Sup 75730, Sup 7, 1125753, 7312, Sup 747, 71
15, Sup 7, 714, Sup 711, Sup 7, 7152, 71100C100C108
Sup 7, 7920, Sup 7, 719, Sup 7Sup 7, 7176
Sup 7, 63, 10624, Sup 740, Sup 748
Sup 7, 9227, Sup 716, Sup 713, Sup 782
8, Sup 7Sup 7, 73103
30, Sup 74, Sup 716, Sup 724, Sup 727, Sup 7Sup 7, 53Sup 7, 5340, Sup 7Sup 7, 73
Year1999199919991999199919991995199920001999201319992006198719941990198719991991
NB: Overall evaluation upgraded to
In prep.Group 2A on the basis of sufficient
evidence in experimental animals with a striking and atypical pattern of tumours
199019991987201320011987199619872013198719872010198719871999199619871993In prep.1993199919871999199919871999199920122012201620011999198719992000201419871987199020101987198719872002198719992013198719871987198719871991199119871999
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
NB: Overall evaluation downgraded to Group 3 with supporting evidence from other relevant data
Additional information
116-14-3Tetrafluoroethylene2A
117-10-2117-39-5117-79-3117-81-7117-81-7118-74-1118-92-3118-96-7119-34-6119-61-9119-90-4119-93-7120-12-7120-58-1120-71-8120-80-9121-14-2121-66-4121-69-7121-75-5121-88-0122-34-9122-42-9122-60-1123-31-9123-33-1123-91-1124-48-1124-58-3124-58-3125-33-7126-07-8Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone)Quercetin
2-Aminoanthraquinone
Bis(2-ethylhexyl) phthalate (see Di(2-ethylhexyl) phthalate)Di(2-ethylhexyl)phthalateHexachlorobenzeneAnthranilic acid2,4,6-Trinitrotoluene4-Amino-2-nitrophenolBenzophenone
3,3'-Dimethoxybenzidine (ortho-Dianisidine)3,3'-Dimethylbenzidine (ortho-Tolidine)AnthraceneIsosafrole
para-CresidineCatechol
2,4-Dinitrotoluene
2-Amino-5-nitrothiazole
N,N-DimethylanilineMalathion
2-Amino-5-nitrophenolSimazineProphamPhenyl glycidyl etherHydroquinoneMaleic hydrazide1,4-Dioxane
ChlorodibromomethaneMethylarsonic acid
Monomethylarsonic acid (see Methylarsonic acid)PrimidoneGriseofulvin2B332B2B3332B2B2B332B2B2B332A3332B332B32B2B2B2B2A2B2B32A33332B332B32B33332B33333
126-72-7Tris(2,3-dibromopropyl) phosphate126-85-2126-99-8127-07-1127-18-4127-69-5128-37-0128-66-5129-00-0129-15-7129-17-9129-20-4129-43-1131-79-3132-27-4132-65-0133-06-2134-32-7135-88-6136-40-3137-17-7137-26-8137-30-4138-59-0139-05-9
Nitrogen mustard N-oxideChloropreneHydroxyurea
Tetrachloroethylene (Perchloroethylene)Sulfafurazole (Sulfisoxazole)Butylated hydroxytoluene (BHT)Vat Yellow 4Pyrene
2-Methyl-1-nitroanthraquinone (uncertain purity)Blue VRS
Oxyphenbutazone
1-HydroxyanthraquinoneYellow OBSodium ortho-phenylphenateDibenzothiopheneCaptan
1-Naphthylamine
N-Phenyl-2-naphthylaminePhenazopyridine hydrochloride2,4,5-TrimethylanilineThiramZiramShikimic acid
Cyclamates (sodium cyclamate)
Agents Classified by the IARC Monographs, Volumes 1–116
CAS No.
139-13-9139-65-1139-94-6140-11-4140-56-7140-57-8140-88-5141-32-2
Agent
Nitrilotriacetic acid and its salts4,4'-ThiodianilineNithiazideBenzyl acetate
para-Dimethylaminoazobenzenediazo sodium sulfonateAramite®Ethyl acrylate
n-Butyl acrylate
Group2B2B3332B2B332B2B2B3333132A3332B2A332B2B3332A333332B2B2B332B3333332B2B32B3333332B32A
Volume48, 7327, Sup 731, Sup 740, Sup 7, 718, Sup 75, Sup 7
39, Sup 7, 7139, Sup 7, 7111, Sup 7, 71Sup 7, 79101
20, Sup 726, Sup 712, Sup 712, Sup 713, Sup 79, Sup 7, 100A40, Sup 7115
16, Sup 7Sup 7, 5312, Sup 79, Sup 7, 7126, Sup 727, Sup 724, Sup 792
Sup 7, 9232, Sup 7, 9292, Sup 792, Sup 7Sup 7, 92Sup 7, 9292
Sup 7, 9292, Sup 792
Sup 7, 92
32, Sup 7, 10392, Sup 792
Sup 7, 9292929292, Sup 792
92, Sup 792, Sup 79292
Sup 7, 929292929292Sup 7, 92Sup 7, 9292
Sup 7, 9232, Sup 7, 103
Year199919871987199919871987199919991999200120131987198719871987198720121987In prep.1987199119871999198719871987201020101987201020102010201020102010201020102010201320102010201020102010201020102010201020102010201020102010201020102010201020102010201020102013
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
NB: Overall evaluation upgraded to Group 2B with supporting evidence from other relevant data
NB: Overall evaluation upgraded to Group 2B with supporting mechanistic and other relevant data
NB: Overall evaluation upgraded to Group 2B with supporting evidence from other relevant data
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
NB: Overall evaluation upgraded to Group 2B with supporting evidence from other relevant dataAdditional information
NB: Evaluated as a group141-37-73,4-Epoxy-6-methylcyclohexylmethyl-3,4-epoxy-6-methylcyclo-hexanecarboxylate141-90-2142-83-6143-50-0143-67-9144-34-3148-18-5148-24-3Thiouracil2,4-Hexadienal
Chlordecone (Kepone)Vinblastine sulfateMethyl selenac
Sodium diethyldithiocarbamate8-Hydroxyquinoline148-82-3Melphalan149-29-1149-30-4150-13-0150-68-5150-69-6
Patulin
2-Mercaptobenzothiazole
para-Aminobenzoic acidMonuronDulcin
151-56-4Aziridine154-93-8156-10-5156-51-41-55-91--0191-07-1191-24-2191-26-4
Bischloroethyl nitrosourea (BCNU)para-NitrosodiphenylaminePhenelzine sulfateDibenzo[a,i]pyreneDibenzo[a,h]pyreneCoronene
Benzo[ghi]peryleneAnthanthrene
191-30-0Dibenzo[a,l]pyrene192-47-2192-51-8192-65-4192-97-2193-09-9193-39-5194-59-2
Dibenzo[h,rst]pentapheneDibenzo[e,l]pyreneDibenzo[a,e]pyreneBenzo[e]pyreneNaphtho[2,3-e]pyreneIndeno[1,2,3-cd]pyrene
7H-Dibenzo[c,g]carbazole
195-19-7Benzo[c]phenanthrene196-78-1Benzo[g]chrysene198-55-0Perylene
202-33-5Benz[j]aceanthrylene202-94-8202-98-2203-12-3203-20-3203-33-8205-12-9205-82-3205-99-2206-44-0207-08-9207-83-0211-91-6213-46-7214-17-5215-58-7217-59-4218-01-9224-41-9
11H-Benz[bc]aceanthrylene4H-Cyclopenta[def]chryseneBenzo[ghi]fluorantheneNaphtho[2,1-a]fluorantheneBenzo[a]fluorantheneBenzo[c]fluoreneBenzo[j]fluorantheneBenzo[b]fluorantheneFluoranthene
Benzo[k]fluoranthene13H-Dibenzo[a,g]fluoreneBenz[l]aceanthrylenePicene
Benzo[b]chryseneDibenz[a,c]anthraceneTriphenyleneChrysene
Dibenz[a,j]anthracene
224-42-0Dibenz[a,j]acridine
224-53-3Dibenz[c,h]acridine225-11-6225-51-4226-36-8238-84-6239-35-0243-17-4262-12-4271--6298-00-0
Benz[a]acridineBenz[c]acridine
Dibenz[a,h]acridineBenzo[a]fluorene
Benzo[b]naphtho[2,1-d]thiopheneBenzo[b]fluoreneDibenzo-para-dioxinBenzofuran
Methyl parathion
2B332B33332B3
103
32, Sup 7, 10332, Sup 7, 10332, Sup 7, 10392, Sup 7103
92, Sup 76963
30, Sup 7
2013201320132013201020132010199719951987
Agents Classified by the IARC Monographs, Volumes 1–116
CAS No.
Agent
Group112A2A2B2B1311332B2A2B2A32B2A2B332B1332A32B313312B32B33332B2B332A32B313332B2A33
298-81-7Methoxsalen (8-methoxypsoralen) plus ultraviolet A radiation299-75-2Treosulfan302-01-2Hydrazine302-17-0Chloral hydrate303-34-4Lasiocarpine303-47-9Ochratoxin A305-03-3Chlorambucil309-00-2Aldrin
313-67-7Aristolochic acid313-67-7314-13-6315-18-4315-22-0
Aristolochic acid, plants containingEvans blueZectran
Monocrotaline
Volume24, Sup 7, 100A
26, Sup 7, 100A
4, Sup 7, 71, 115
63, 84, 10610, Sup 7Sup 7, 5626, Sup 7, 100A5, Sup 782, 100A82, 100A8, Sup 712, Sup 710, Sup 750561127, Sup 711026, Sup 7108
11, Sup 7Sup 7, 6613, Sup 726, Sup 7, 100A10, Sup 710, Sup 740, Sup 716, Sup 71, Sup 7, 99, 100F8, Sup 74, Sup 7, 100A16, Sup 779
9, Sup 7, 100F65
30, Sup 763
40, Sup 731, Sup 78, Sup 740, Sup 79, Sup 77, Sup 78, Sup 713, Sup 74, Sup 7, 7173
41, Sup 7, 7136, Sup 7, 714, Sup 7, 100F52, 719, Sup 79, Sup 77, Sup 77779
12, Sup 7
Year20122012In prep.201419871993201219872012201219871987198719901993
NB: Overall evaluation upgraded to
In prep.Group 2A based on mechanistic
evidence
1987In prep.
NB: Overall evaluation upgraded to
1987Group 2A with supporting evidence
from other relevant data
20161987199619872012198719871987198720121987201219872001201219961987199519871987198719871987198719871987199919991999199920121999198719871987200020011987
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data
Additional information
320-67-2Azacitidine331-39-5Caffeic acid333-41-5Diazinon
334-88-3Diazomethane
335-67-1Perfluorooctanoic acid (PFOA)366-70-1Procarbazine hydrochloride396-01-0Triamterene420-12-2Ethylene sulfide439-14-5Diazepam443-48-1Metronidazole446-86-6Azathioprine480-54-6Retrorsine480-81-9Seneciphylline484-20-85-Methoxypsoralen492-17-12,4'-Diphenyldiamine492-80-8Auramine493-52-7Methyl red494-03-1Chlornaphazine494-03-1494-38-2501-30-4505-60-2N,N-Bis(2-chloroethyl)-2-naphthylamine (see Chlornaphazine)Acridine orangeKojic acid
Mustard gas (see Sulfur mustard)505-60-2Sulfur mustard509-14-8510-15-6513-37-1518-75-2520-18-3523-44-4523-44-4523-50-2531-76-0531-82-8532-82-1536-33-4
TetranitromethaneChlorobenzilate1-Chloro-2-methylpropeneCitrininKaempferol
CI Acid Orange 20Orange I (see CI Acid Orange 20)Angelicin plus ultraviolet A radiationMerphalan
N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamideChrysoidineEthionamide
540-73-81,2-Dimethylhydrazine541-73-1542-75-6542-78-9542-88-1
107-30-2545-06-2545-55-1551-74-6555-84-0
meta-Dichlorobenzene
1,3-Dichloropropene (technical-grade)Malonaldehyde
Bis(chloromethyl)ether; chloromethyl methyl ether (technical-grade)Trichloroacetonitrile
Tris(1-aziridinyl)phosphine oxideMannomustine dihydrochloride1-[(5-Nitrofurfurylidene)amino]-2-imidazolidinone
556-52-5Glycidol
562-10-7Doxylamine succinate
563-41-7Semicarbazide hydrochloride
Agents Classified by the IARC Monographs, Volumes 1–116
CAS No.
563-47-3569-61-9581--5592-62-1
Agent
3-Chloro-2-methylpropene, technical gradeCI Basic Red 92-Nitronaphthalene
Methylazoxymethanol acetate
Group2B2B32B
Volume63, 11557, 9946
10, Sup 7
YearIn prep.2010191987
Additional information
593-60-2Vinyl bromide2A
39, Sup 7, 71, 97
2008
NB: (1) Overall evaluation upgraded to Group 2A based on mechanistic and other relevant data;
(2) For practical purposes, vinyl bromide should be considered to act similarly to the human carcinogen vinyl chloride
593-70-4598-55-0599-79-1602-60-8602-87-9604-75-1606-20-2607-57-8609-20-1613-35-4615-05-4615-53-2618-85-9621--7627-12-3ChlorofluoromethaneMethyl carbamateSulfasalazine9-Nitroanthracene5-NitroacenaphtheneOxazepam2,6-Dinitrotoluene2-Nitrofluorene
2,6-Dichloro-para-phenylenediamineN,N'-Diacetylbenzidine2,4-Diaminoanisole
N-Methyl-N-nitrosourethane3,5-Dinitrotoluene
N-Nitrosodi-n-propylaminen-Propyl carbamate332B32B2B2B2B32B2B2B32B32B2B2B332B2A2B2B32A2B332B332B2B332B333332B2B32A32B2A3332B2B333
630-20-61,1,1,2-Tetrachloroethane631--1Dibromoacetic acid632-99-5Magenta
637-07-0Clofibrate
1-48-5Dihydroaceanthrylene
680-31-9Hexamethylphosphoramide684-93-5N-Methyl-N-nitrosourea693-98-12-Methylimidazole712-68-52-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole723-46-6Sulfamethoxazole
759-73-9N-Ethyl-N-nitrosourea765-34-47-07-1794-93-4794-93-4800-24-8804-36-4817-09-4822-36-6828-00-2832-69-9838-88-0842-07-9846-50-4868-85-92-21-7915-67-3924-16-3930-55-29-38-81071-83-61072-52-21116-54-7
Glycidaldehyde2-Nitropyrene
Dihydroxymethylfuratrizine (see also Panfuran S)Panfuran S (containing dihydroxymethylfuratrizine)Aziridyl benzoquinoneNitrovin
Trichlormethine (Trimustine hydrochloride)4-MethylimidazoleDimethoxane
1-Methylphenanthrene
4,4'-Methylene bis(2-methylaniline)Sudan ITemazepam
Dimethyl hydrogen phosphite3-NitrofluorantheneAmaranthN-Nitrosodi-n-butylamineN-NitrosopyrrolidineRhodamine 6GGlyphosate2-(1-Aziridinyl)ethanol
N-Nitrosodiethanolamine
41, Sup 7, 7112, Sup 7108
33, Sup 716, Sup 7Sup 7, 666546, 10539, Sup 716, Sup 7Sup 7, 794, Sup 765
17, Sup 712, Sup 741, Sup 7, 71, 106101
Sup 7, 57, 99, 100FSup 7, 6692
15, Sup 7, 7117, Sup 71017, Sup 7Sup 7, 7917, Sup 711, Sup 7, 7146
24, Sup 724, Sup 79, Sup 731, Sup 7Sup 7, 5010115, Sup 7Sup 7, 924, Sup 78, Sup 768, 7133, Sup 78, Sup 717, Sup 717, Sup 716, Sup 71129, Sup 7
17, Sup 7, 774, Sup 7, 71, 11013; Sup 748, 7186, 100C1, Sup 74786
1, Sup 76847, 71
1999198720161987198719961996201319871987200119871996198719872014201320121996201019991987201319872001198719991919871987198719871990201319872010198719871996199919871987198719871987In prep.19872000
NB: Overall evaluation upgraded to
In prep.Group 2A with supporting evidence
from other relevant data
1987199920121987192006198719971999
NB: Mineral substances (e.g. talc or vermiculite) that contain asbestos
should also be regarded as carcinogenic to humans
*The presence of an asterisk indicates that the registration is for a substance which CAS does not treat in its regular CA index
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
1120-71-41,3-Propane sultone
Dithranol
Decabromodiphenyl oxide
Gallium arsenide (see Arsenic and inorganic arsenic compounds)Ferric oxide
Antimony trioxideVanadium pentoxideHaematite
Zeolites other than erionite (clinoptilolite, phillipsite,mordenite, non-fibrous Japanese
1318-02-1
zeolite, synthetic zeolites)
1330-20-7Xylenes
1332-21-4
77536-67-5*
12172-73-5
Asbestos (all forms, including actinolite, amosite, anthophyllite, chrysotile, crocidolite,
77536-66-4*
tremolite)
12001-29-5
12001-28-4
77536-68-6*
1143-38-01163-19-51303-00-01309-37-11309--41314-62-11317-60-8
1
14, Sup 7, 100C
2012
Agents Classified by the IARC Monographs, Volumes 1–116
CAS No.
1333-86-41336-36-31338-16-51345-04-61401-55-4Agent
Carbon blackPolychlorinated biphenyls
Iron sorbitol-citric acid complexAntimony trisulfideTannic acid and tanninsGroup2B1333132B3332B3312B2B3
VolumeSup 7, 65, 9318, Sup 7, 1072, Sup 747
10, Sup 756, 82, 100F, Sup 711, Sup 7534, Sup 7, 717347, 718, Sup 716, Sup 7Sup 7, 92Sup 7, 92Sup 7, 69, 100F30, Sup 7Sup 7, 7353, 7353
8, Sup 7
Year2010201619871919872012198719911999199919991987198720102010201219871999199919911987
NB: Overall evaluation downgraded to Group 3 with supporting evidence from other relevant data
Additional information
1402-68-2Aflatoxins14-53-51582-09-81615-80-11634-04-41675-54-316-82-31694-09-31705-85-71706-01-0
1,2:3,4-Diepoxybutane (see Monographs on 1,3-Butadiene)Trifluralin1,2-Diethylhydrazine
Methyl tert-butyl ether
Bisphenol A diglycidyl ether (Araldite)4-HydroxyazobenzeneBenzyl violet 4B6-Methylchrysene3-Methylfluoranthene
1746-01-62,3,7,8-Tetrachlorodibenzo-para-dioxin1836-75-5Nitrofen (technical-grade)17-45-6Chlorothalonil1912-24-9Atrazine1918-02-11936-15-81936-15-81937-37-71954-28-52068-78-221-17-22168-68-52243-62-12303-16-42318-18-52353-45-92385-85-52386-90-5
Picloram3CI Orange G3Orange G (see CI Orange G)CI Direct Black 38 (see Benzidine, dyes metabolized to)Triethylene glycol diglycidyl ether3Vincristine sulfate3Fluometuron3Bis(1-aziridinyl)morpholinophosphine sulfide31,5-Naphthalenediamine3Diallate3Senkirkine3Fast Green FCF3Mirex2BBis(2,3-epoxycyclopentyl)ether 32A32B32B2B332B33332B32B332B2B33332B32B2B2B2B2B32B33332B32B333333
2425-06-1Captafol2425-85-62429-74-52432-99-72475-45-82602-46-226-17-52757-90-62783-94-02784-94-32832-40-82835-39-42871-01-42955-38-62973-10-63018-12-03068-88-03118-97-63173-72-63252-43-53296-90-03351-28-83351-30-23351-31-33351-32-435-09-83567-69-93570-75-03688-53-73697-24-33761-53-33771-19-53778-73-23795-88-83844-45-93902-71-44063-41-170-30-34342-03-44548-53-24549-40-04657-93-680-78-85131-60-25141-20-85160-02-15307-14-2
CI Pigment Red 3CI Direct Blue 1511-Aminoundecanoic acidDisperse Blue 1
CI Direct Blue 6 (see Benzidine, dyes metabolized to)Oil Orange SSAgaritine
Sunset Yellow FCFHC Blue No. 1Disperse Yellow 3Allyl isovalerateHC Red No. 3Prazepam
Diisopropyl sulfateDichloroacetonitrilebeta-ButyrolactoneSudan II
1,5-Naphthalene diisocyanateDibromoacetonitrile2,2-Bis(bromomethyl)propane-1,3-diol1-Methylchrysene4-Methylchrysene3-Methylchrysene2-MethylchrysenePonceau 3RCarmoisine
2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazoleAF-2 [2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide]5-MethylchrysenePonceau MXNafenopin
Isophosphamide
5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)-amino]-2-oxazolidinoneBrilliant Blue FCF, disodium salt4,5',8-Trimethylpsoralen
4,5'-Dimethylangelicin plus ultraviolet A radiationCrotonaldehydeDacarbazinePonceau SX
N-Nitrosomethylvinylamine5-AminoacenaphtheneGuinea Green B
4-Chloro-meta-phenylenediamineLight Green SFD & C Red No. 9
1,4-Diamino-2-nitrobenzene
11, Sup 7, 71199926, Sup 7198730, Sup 719879, Sup 7198727, Sup 7198730, Sup 7198731, Sup 7198716, Sup 7198720, Sup 71987
47, 711999
NB: Overall evaluation upgraded to
531991Group 2A with supporting evidence
from other relevant data
57199357199339, Sup 719874819908, Sup 731, Sup 78, Sup 75748
36, Sup 7, 71576654, 7152, 7111, Sup 7, 718, Sup 7
19, Sup 7, 7152, 71, 10177
Sup 7, 92Sup 7, 92Sup 7, 92Sup 7, 928, Sup 78, Sup 77, Sup 731, Sup 7Sup 7, 928, Sup 724, Sup 726, Sup 77, Sup 716, Sup 740, Sup 7Sup 763
26, Sup 78, Sup 717, Sup 716, Sup 716, Sup 727, Sup 716, Sup 7Sup 7, 57Sup 7, 57
19871987198719931990199919931996199919991999198719992013200020102010201020101987198719871987201019871987198719871987198719871995198719871987198719871987198719931993
Agents Classified by the IARC Monographs, Volumes 1–116
CAS No.Agent
5385-75-1Dibenzo[a,e]fluoranthene5431-33-4Glycidyl oleate5456-28-0Ethyl selenac
5522-43-01-Nitropyrene55-96-8Bromochloroacetic acid59-27-5d-Limonene61-98-36358-53-86368-72-56373-74-616-57-559-94-56795-23-96870-67-37099-43-67220-79-37439-92-17439-97-67440-02-07440-07-57440-29-1
ChlordimeformCitrus Red No. 2Sudan Red 7BCI Acid Orange 3Sudan Brown RRCI Acid Red 114Aflatoxin M1Jacobine
5,6-Cyclopenteno-1,2-benzanthraceneMethylene blueLead
Mercury and inorganic mercury compoundsNickel, metallic and alloysPlutonium
Thorium-232 and its decay products
Group3332A2B332B3332B2B3332B32B1111132B2B2A332B2A333332B332B32A3133VolumeSup 7, 9211, Sup 712, Sup 7Sup 7, 46, 10510156, 7330, Sup 78, Sup 78, Sup 757
8, Sup 7575610, Sup 792108
23, Sup 758
Sup 7, 4978, 100D78, 100D23, Sup 7, 100C
Sup 7, 58, 100C58, 100CSup 7, 4952868654
11, Sup 776Sup 7, 46, 10517, Sup 739, Sup 7, 71Sup 7, 6854
36, Sup 7, 71Sup 7, 7352
9, Sup 7Sup 7, 795, Sup 7Sup 7, 9245
35, Sup 792, 100F13, Sup 72, Sup 735, Sup 7
2B32B33333333333332B333332B1
10331, Sup 7108
19, Sup 719, Sup 719, Sup 719, Sup 719, Sup 719, Sup 719, Sup 719, Sup 719, Sup 7, 7119, Sup 719, Sup .719, Sup 72, Sup 72, Sup 719, Sup 719, Sup 719, Sup 719, Sup 719, Sup 786
43, 78, 100D
Year20101987198720142013199919871987198719931987199319931987201020161987199319902012201220122012201219901991200620061992198720002014198719991997199219991999199119872001198720101919872012198719871987201319872016198719871987198719871987198719871987198719871987198719871987198719871987198720062012
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
NB: Overall evaluation downgraded to Group 3 with supporting evidence from other relevant data
Additional information
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
7440-38-2Arsenic and inorganic arsenic compounds7440-41-7Beryllium and beryllium compounds7440-43-97440-47-37440-48-47440-48-47440-48-4
12070-12-17446-09-57460-84-67481--2Cadmium and cadmium compoundsChromium, metallic
Cobalt and cobalt compounds
Cobalt metal without tungsten carbideCobalt metal with tungsten carbideSulfur dioxideGlycidyl stearateZalcitabineNB: Evaluated as a group
7496-02-86-Nitrochrysene7519-36-07572-29-47631-86-977-01-076-93-97722-84-17758-01-27758-19-27782-49-28001-35-28001-50-18001-58-98002-05-98007-45-28007-45-28018-07-38047-67-48052-42-48052-42-4
741-56-69000-07-19000-38-002-84-09002-86-29002-88-49002--59003-01-49003-07-09003-20-79003-22-99003-39-003-53-69003-54-79003-55-004-51-79004-66-49009-54-59010-98-49011-06-79011-14-79016-87-910026-24-110043-66-010043-92-2
N-NitrosoprolineDichloroacetyleneSilica, amorphousHydrochloric acid
Strong-inorganic-acid mists containing sulfuric acid (see Acid mists)Hydrogen peroxidePotassium bromateSodium chlorite
Selenium and selenium compounds
Toxaphene (Polychlorinated camphenes)Terpene polychlorinates (Strobane®)CreosotesCrude oil
Coal tars (see Coal-tar distillation)Coal-tar distillationAcriflavinium chlorideSaccharated iron oxideBitumens, extracts of steam-refined and air-refined; steam-refined, cracking-residue and air-refined bitumens (see Bitumens, occupational exposures)
Bitumens, occupational exposure to straight-run bitumens and their emissions during road paving
Carrageenan, nativeKava extract
PolytetrafluoroethylenePolyvinyl chloridePolyethylenePolyvinyl alcoholPolyacrylic acidPolypropylenePolyvinyl acetate
Vinyl chloride-vinyl acetate copolymersPolyvinyl pyrrolidonePolystyreneStyrene-acrylonitrile copolymersStyrene-butadiene copolymersIron-dextrin complexIron-dextran complexPolyurethane foamsPolychloroprene
Vinylidene chloride-vinyl chloride copolymersPolymethyl methacrylate
Polymethylene polyphenyl isocyanate
Cobalt sulfate and other soluble cobalt(II) saltsIodine-131 (see Radioiodines)Radon-222 and its decay products
Agents Classified by the IARC Monographs, Volumes 1–116
CAS No.
10048-13-210048-32-510098-97-210380-28-6
Agent
SterigmatocystinParasorbic acid
Strontium-90 (see Fission products)Copper 8-hydroxyquinoline
Group2B3312B32B3
Volume10, Sup 710, Sup 715, Sup 766, 100A17, Sup 78426, Sup 776
Year19871987198720121987200419872000
NB: Overall evaluation upgraded to Group 2B with supporting evidence from other relevant data
NB: There is also conclusive evidence that tamoxifen reduces the risk of contralateral breast cancer in breast cancer patients
Additional information
10540-29-1Tamoxifen
10595-95-6N-Nitrosomethylethylamine10599-90-3Chloramine11056-06-7Bleomycins12001-79-512070-12-1
7440-48-412122-67-712174-11-712174-11-712174-11-712192-57-312427-38-212663-46-6
Vitamin K substances
Tungsten carbide with cobalt metal (see Cobalt metal with tungsten carbide)ZinebAttapulgite (see Palygorskite)
Palygorskite (Attapulgite) (long fibres, > 5 micrometres)Palygorskite (Attapulgite)(short fibres, < 5 micrometres)AurothioglucoseManeb
Cyclochlorotine
32B33332A312B32B3
12, Sup 76868
13, Sup 712, Sup 710, Sup 726, Sup 79, Sup 778, 100D17, Sup 724, Sup 747, 93
15; Sup 7, 71
1987199719971987198719871987198720121987198720101999
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
13010-47-41-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)13045-94-813233-32-413256-22-913292-46-113463-67-713483-18-6
Medphalan
Radium-224 and its decay productsN-NitrososarcosineRifampicinTitanium dioxide
1,2-Bis(chloromethoxy)ethane
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (Methyl-CCNU) (see
13909-09-6
Semustine)13909-09-6Semustine [1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea, Methyl-CCNU]13982-63-313983-17-014484--114596-37-314807-96-614807-96-614807-96-6
Radium-226 and its decay productsWollastoniteFerbam
Phosphorus-32, as phosphate
Talc containing asbestiform fibres (see Asbestos)Talc not containing asbestos or asbestiform fibresTalc-based body powder (perineal use of)
1133132B12B31332A33Sup 7, 100A78, 100DSup 7, 6812, Sup 778, 100D42, Sup 742, Sup 7, 9393
Sup 7, 68, 100C10, Sup 715, Sup 778, 100DSup 7, 6810, Sup 726, Sup 727, Sup 749Sup 7, , 100E31, Sup 727, Sup 7105
Sup 7, 49, 100C17, Sup 740, Sup 746108
10, Sup 712, Sup 710, Sup 7
30, Sup 7, 112Sup 7, 9286, 65, 10531, Sup 79, Sup 7Sup 710, Sup 710, Sup 7, 82
20122012199719872012198720102010201219871987201219971987198719871990NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
14808-60-7Silica dust, crystalline, in the form of quartz or cristobalite14901-08-715086-94-915262-20-115501-74-315503-86-3
CycasinEosin
Radium-228 and its decay productsSepioliteIsatidine
15663-27-1Cisplatin
15721-02-52,2',5,5'-Tetrachlorobenzidine16065-83-1Chromium (III) compounds16071-86-6CI Direct Brown 95 (see Benzidine, dyes metabolized to)
16543-55-8
N'-Nitrosonornicotine (NNN) and 4-(N-Nitrosomethylamino)-1-(3-091-91-4pyridyl)-1-butanone (NNK)
16568-02-8Gyromitrin
16984-48-8Fluorides (inorganic, used in drinking-water)17117-34-93-Nitrobenzanthrone18540-29-9Chromium (VI) compounds18883-66-420073-24-920268-51-3205-63-320830-75-520830-81-320941-65-521884-44-622248-79-922349-59-3Streptozotocin3-Carbethoxypsoralen
7-Nitrobenz[a]anthracene3-NitroperyleneDigoxinDaunomycinEthyl telluracLuteoskyrin
Tetrachlorvinphos
1,4-Dimethylphenanthrene1332B12B3332B2B332B32A2B3332A2B
201219871987201420121987198719192016198719871987In prep.20102006201319871987198719872002
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
22398-80-7Indium phosphide22506-53-222571-95-522966-79-622975-76-4
3,9-DinitrofluorantheneSymphytineOestradiol mustard
4,4'-Dimethylangelicin plus ultraviolet A radiation
NB: Overall evaluation upgraded to Group 2A
23214-92-8Adriamycin23246-96-0Riddelliine
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
Agents Classified by the IARC Monographs, Volumes 1–116
CAS No.
23255-93-823537-16-823746-34-124560-98-324938--525013-15-425013-16-525038-54-425732-74-525812-30-025962-77-026148-68-526308-28-1271-62-526782-43-4
Agent
Hycanthone mesylateRugulosin
Potassium bis(2-hydroxyethyl)dithiocarbamatecis-9,10-Epoxystearic acidpara-Aramid fibrilsVinyl toluene
Butylated hydroxyanisole (BHA)Nylon 6
Acepyrene (3,4-dihydrocyclopenta[cd]pyrene)Gemfibrozil
trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2-furyl)-vinyl]-1,3,4-oxadiazole
A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole)Ripazepam
Toluene diisocyanatesHydroxysenkirkine
Group3333332B3332B2B32B32A2B332A332B31
Volume13, Sup 740, Sup 712, Sup 711, Sup 7, 716860
40, Sup 719, Sup 792667, Sup 740, Sup 766
39, Sup 7, 7110, Sup 7Sup 7, 9216, Sup 750
17, Sup 7766617, Sup 7765776, 100A
Year1987198719871999199719941987198720101996198719871996199919872010198719901987200019961987200019932012
NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
Additional information
27208-37-3Cyclopenta[cd]pyrene
28434-86-83,3'-Dichloro-4,4'-diaminodiphenyl ether29069-24-7Prednimustine
29291-35-8N-Nitrosofolic acid29767-20-2Teniposide29975-16-430310-80-630516-87-133229-34-4
EstazolamN-NitrosohydroxyprolineZidovudine (AZT)HC Blue No. 2
33419-42-0Etoposide33419-42-0
15663-27-1
11056-06-733543-31-637319-17-837620-20-538571-73-240762-15-042397--842397-65-9512-14-351481-61-951630-58-1525-53-152918-63-553973-98-153973-98-1
Etoposide in combination with cisplatin and bleomycin2-Methylfluoranthene
Pentosan polysulfate sodium
N'-Nitrosoanabasine (NAB)1,2,3-Tris(chloromethoxy)propaneDoxefazepam1,6-Dinitropyrene1,8-DinitropyreneAmsacrineCimetidineFenvaleratePermethrinDeltamethrin
Carrageenan, degraded (Poligeenan)Poligeenan (see Carrageenan, degraded)
132B3332B2B2B33332B
76, 100ASup 7, 92108
37, Sup 7, 15, Sup 7, 7166
46, 105
Sup 7, 46, 1057650535353
31, Sup 7
20122010201620071999199620132013200019901991199119911987
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
54749-90-5Chlorozotocin55557-01-255557-02-35-91-857018-52-7
N-NitrosoguvacineN-Nitrosoguvacoline
1,4-Bis(chloromethoxymethyl)benzene1-tert-Butoxypropan-2-ol
2A3333112B350
Sup 7, 85Sup 7, 8515; Sup 7, 7188100F100F46, 1057619902004200419992006201220122013200057117-31-42,3,4,7,8-Pentachlorodibenzofuran57465-28-83,4,5,3’,4’-Pentachlorobiphenyl (PCB-126)57835-92-44-Nitropyrene59277--3AciclovirNB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data
See Polychlorinated biphenyls, dioxin-like, with a TEF according to WHO
59536-65-1Polybrominated biphenyls2A41, Sup 7, 1072016
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data, namely mechanistic similarity with
polychlorinated biphenyls classified in Group 1
59820-43-859865-13-3
79217-60-059865-13-3
79217-60-060102-37-660153-49-362450-06-062450-07-163041-90-7
HC Yellow No. 4
Ciclosporin (see Cyclosporine)Cyclosporine
Petasitenine
3-(N-Nitrosomethylamino)propionitrileTrp-P-1 (3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole)Trp-P-2 (3-Amino-1-methyl-5H-pyrido[4,3-b]indole)6-Nitrobenzo[a]pyrene
3571993
132B2B2B332A2B1
50, 100A31, Sup 7Sup 7, 8531, Sup 731, Sup 7Sup 7, 46100C1037635, Sup 7, 100F
20121987200419871987192012201320002012
436-13-1Arsenobetaine and other organic arsenic compounds that are not metabolized in humansBitumens, occupational exposure to oxidized bitumens and their emissions during roofing
65271-80-9Mitoxantrone742-93-4
65996-93-2Coal-tar pitch
Agents Classified by the IARC Monographs, Volumes 1–116
CAS No.
66733-21-9Erionite
67730-10-3Glu-P-2 (2-Aminodipyrido[1,2-a:3',2'-d]imidazole)67730-11-4Glu-P-1 (2-Amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole)68006-83-7MeA-alpha-C (2-Amino-3-methyl-9H-pyrido[2,3-b]indole)68308-34-9Shale oils68603-42-969655-05-671267-22-673459-03-775321-20-9
Coconut oil diethanolamine condensateDidanosineN'-Nitrosoanatabine (NAT)
5-Methylangelicin plus ultraviolet A radiation1,3-Dinitropyrene
Agent
Group12B2B2B12B3332B2A2B2B2B33333332B332B2B2B2A32B2B332B33
Volume42, Sup 7, 100C40, Sup 740, Sup 740, Sup 735, Sup 7, 100F1017637, Sup 7, Sup 746, 105Sup 7, 56Sup 7, 5684Sup 7, 566652, 71Sup 7, 8540, Sup 740, Sup 740, Sup 766108Sup 7609456
46, 65, 105102825694108111111111
Year201219871987198720122013200020071987201319931993200419931996199920041987198719871996201619871994201019932013201620102002199320102016In prep.In prep.In prep.
NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data
Additional information
76180-96-6IQ (2-Amino-3-methylimidazo[4,5-f]quinoline)
77094-11-2MeIQ (2-Amino-3,4-dimethylimidazo[4,5-f]quinoline)77439-76-03-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone77500-04-0MeIQx (2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline)82413-20-5Droloxifene
83463-62-1Bromochloroacetonitrile
85502-23-43-(N-Nitrosomethylamino)propionaldehyde85878-62-2Pyrido[3,4-c]psoralen
85878-63-37-Methylpyrido[3,4-c]psoralen87625-62-5Ptaquiloside778-26-7Toremifene
90045-36-6Ginkgo biloba extract90370-29-94,4',6-Trimethylangelicin plus ultraviolet A radiation90456-67-0 [deleted]
N-Methylolacrylamide
924-42-5
101043-37-2Microcystin-LR
105650-23-5PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)105735-71-53,7-Dinitrofluoranthene111025-46-8Pioglitazone1111-32-3Naphtho[1,2-b]fluoranthene116355-83-0Fumonisin B1
Fusarium moniliforme, toxins derived from (fumonisin B1,
116355-83-0
fumonisin B2, and fusarin C)
118399-22-7Nodularins122320-73-4Rosiglitazone
308068-56-6Carbon nanotubes, multi-walled MWCNT-7308068-56-6Carbon nanotubes, multi-walled, other than MWCNT-7308068-56-6Carbon nanotubes, single-walled
Multi-walled carbon nanotubes MWCNT-7 (see Carbon nanotubes, multi-walled
308068-56-6
MWCNT-7)
Multi-walled carbon nanotubes other than MWCNT-7 (see Carbon nanotubes, multi-308068-56-6
walled, other than MWCNT-7)
308068-56-6Single-walled carbon nanotubes (see Carbon nanotubes, single-walled)308076-74-6Silicon carbide, fibrous409-21-2Silicon carbide whiskers
Acheson process, occupational exposure associated withAcid mists, strong inorganicAcrylic fibresAcrylonitrile-butadiene-styrene copolymersAlcoholic beverages
Aloe vera, whole leaf extractAlpha particles (see Radionuclides)Aluminium production
Anaesthetics, volatile
Androgenic (anabolic) steroidsAreca nut
Art glass, glass containers and pressed ware (manufacture of)Auramine productionBenzidine, dyes metabolized toBeta particles (see Radionuclides)Betel quid with tobaccoBetel quid without tobacco
Biomass fuel (primarily wood), indoor emissions from household combustion ofBisulfites
Bitumens, occupational exposure to hard bitumens and their emissions during mastic asphalt work
BK polyomavirus (BKV)Boot and shoe manufacture and repair (see Leather dust, Benzene)Bracken fern
Calcium carbide productionCarbon electrode manufactureCarpentry and joinery
Chimney sweeping (see Soot)Chlorinated drinking-water
2B2A113312B132A12A11
111111111
54, 100F19, Sup 719, Sup 744, 96, 100E108
34, Sup 7, 92, 100F11, Sup 7Sup 785, 100E58
Sup 7, 99, 100F99, 100F
In prep.In prep.In prep.201219871987201220162012198719872012199320122012
NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data
112A32B2B2B32A2B3
Sup 7, 85, 100E
Sup 7, 85, 100E955410310425, Sup 740, Sup 7929225, Sup 79252
2012201220101992201320131987198720102010198720101991
Agents Classified by the IARC Monographs, Volumes 1–116
CAS No.
Agent
Chlorinated paraffins of average carbon chain length C12 and average degree of chlorination approximately 60%
Chlorophenols (see Polychlorophenols)Chlorophenoxy herbicides
Clonorchis sinensis (infection with)Coal dustCoal gasification
Coal, indoor emissions from household combustion ofGroup2B2B13114841, Sup 761, 100B68
Sup 7, 92, 100F95, 100EVolume
Year199019872012199720122012NB:Thereisevidencesuggestinglackofcarcinogenicityinhumansofcoffeedrinkingforcancersofthepancreas,liver,femalebreast,uterine
In prep.
endometrium,andprostate.Inverseassociationswithcoffeedrinkinghavebeenobservedwithcancersoftheliverand uterine endometrium. 2012
Additional information
Coffee (drinking)351, 116
Coke production
Continuous glass filament (see Glass filament)Diesel engine exhaust (see Engine exhaust, diesel)Diesel fuel, marine
Diesel fuels, distillate (light)Dry cleaning (occupational exposures in)
Dyes metabolized to benzidine (see Benzidine, dyes metabolized to)Electric fields, extremely low-frequencyElectric fields, staticEngine exhaust, dieselEngine exhaust, gasolineEpstein-Barr virus
Estrogen therapy, postmenopausalEstrogen-progestogen menopausal therapy (combined)Estrogen-progestogen oral contraceptives (combined)Firefighter (occupational exposure as a)Fission products, including strontium-90
Flat-glass and specialty glass (manufacture of)Fluorescent lighting
Fluoro-edenite fibrous amphibole
Foreign bodies (see Surgical implants and other foreign bodies)Frying, emissions from high-temperatureFuel oils, distillate (light)Fuel oils, residual (heavy)
Furniture and cabinet making (see Wood dust)
Fusarium graminearum, F. culmorum, and F. crookwellense, toxins derived from (zearalenone, deoxynivalenol, nivalenol, and fusarenone X)Fusarium sporotrichioides, toxins derived from (T-2 toxin)Gamma-Radiation (see X- and Gamma-Radiation)Gasoline
Gasoline engine exhaust (see Engine exhaust, gasoline)Glass filament, continuousGoldenseal root powderHaematite mining (underground)
Hair colouring products (personal use of)Hairdresser or barber (occupational exposure as a)Helicobacter pylori (infection with)Hepatitis B virus (chronic infection with)Hepatitis C virus (chronic infection with)Hepatitis D virus
Hexachlorocyclohexanes
High-temperature frying (see Frying)
Household combustion of biomass fuel (see Biomass fuel, indoor emissions from household combustion of)
Household combustion of coal (see Coal, indoor emissions from household combustion)Human herpesvirus type 4 (see Epstein-Barr virus)
Human herpesvirus type 8 (see Kaposi sarcoma herpesvirus)Human immunodeficiency virus type 1 (infection with)Human immunodeficiency virus type 2 (infection with)
Human papillomavirus genus beta (except types 5 and 8) and genus gammaHuman papillomavirus type 68Human papillomavirus types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59Human papillomavirus types 26, 53, 66, 67, 70, 73, 82
1
Sup 7, 92, 100F
2B32B3312B11112B13312A32B
454563
808046, 10546, 10570, 100B72, 100A72, 91, 100A72, 91, 100A98100D5855111954545
25, Sup 7Sup 7, 5656
19191995200220022013201320122012201220122010201219931992In prep.20101919198719931993
NB: Overall evaluation upgraded to Group 2B with supporting evidence from other relevant data
NB: There is also convincing evidence in humans that these agents confer a protective effect against cancer in the endometrium and ovary
33
2B4519
NB: Overall evaluation upgraded to Group 2B with supporting evidence from other relevant data
32B132A11132B43, 81108
1, Sup 7, 100D57, 9957, 9961, 100B59, 100B59, 100B59
20, Sup 7
2002201620122010201020122012201219941987
12B32A12B
67, 100B67
90, 100B100B, 90, 100B100B
201219962012201220122012
NB: The HPV types that have been
classified as carcinogenic to humans can differ by an order of magnitude in risk for cervical cancer
Agents Classified by the IARC Monographs, Volumes 1–116
CAS No.
Agent
Human papillomavirus types 30, 34, 69, 85, 97
Human papillomavirus types 5 and 8 (in patients with epidermodysplasia verruciformis)Human papillomavirus types 6 and 11Human T-cell lymphotropic virus type IHuman T-cell lymphotropic virus type IIHypochlorite saltsInsulation glass wool
Involuntary smoking (see Tobacco smoke, second-hand)Ionizing radiation (all types)
Iron and steel founding (occupational exposure during)Isopropyl alcohol manufacture using strong acidsIsopropyl oils
JC polyomavirus (JCV)Jet fuel
Kaposi sarcoma herpesvirusLead compounds, inorganic
Group2B2B3133311132B312A
Volume100B100B90, 100B67, 100B675243, 81100D
34, Sup 7, 100F
Sup 7, 100F15, Sup 7, 7110445
70, 100BSup 7, 87
Year2012201220122012199619912002201220122012199920131920122006
NB: Organic lead compounds are
metabolized at least in part, to ionic lead both in humans and animals. To the extent that ionic lead, generated from organic lead, is present in the body, it will be expected to exert the toxicities associated with inorganic lead
Additional information
NB: Classified by phylogenetic analogy to the HPV genus alpha types classified in Group 1
Lead compounds, organic323, Sup 7, 872006
Leather dust
Leather goods manufactureLeather tanning and processing
Lumber and sawmill industries (including logging)Madder root (Rubia tinctorum)Magenta production
Magnetic fields, extremely low-frequencyMagnetic fields, static
Malaria (caused by infection with Plasmodium falciparum in holoendemic areas)
Mate, not very hot (drinking)
Mate, hot (see Very hot beverages)Merkel cell polyomavirus (MCV)Metabisulfites
Methylmercury compoundsMicrocystis extractsMineral oils, highly-refined
Mineral oils, untreated or mildly treated
Modacrylic fibres
MOPP and other combined chemotherapy including alkylating agentsNeutron radiationNickel compounds
Nickel refining (see Nickel compounds)
Nitrate or nitrite (ingested) under conditions that result in endogenous nitrosationNon-arsenical insecticides (occupational exposures in spraying and application of)Oestrogen (see Estrogen)Opisthorchis felineus (infection with)Opisthorchis viverrini (infection with)
Oral contraceptives, combined estrogen-progestogen (see Estrogen-progestogen oral contraceptives)
Outdoor air pollution
Outdoor air pollution, particulate matter inPaint manufacture (occupational exposure in)Painter (occupational exposure as a)Particulate matter in outdoor air pollution (see Outdoor air pollution, particulate matter in)
Paving and roofing with coal-tar pitch (see Coal-tar pitch)Petroleum refining (occupational exposures in)Petroleum solvents
Phenacetin, analgesic mixtures containingPickled vegetables (traditional Asian)
Polychlorinated biphenyls, dioxin-like, with a Toxicity Equivalency Factor (TEF) according to WHO (PCBs 77, 81, 105, 114, 118, 123, 126, 156, 157, 167, 169, 1)Polychlorinated dibenzofurans (see 2,3,4,7,8-Pentachlorodibenzofuran)
Polychlorinated dibenzo-para-dioxins (other than 2,3,7,8-tetrachlorodibenzo-para-dioxin)
Polychlorophenols and their sodium salts (mixed exposures)Printing inks
Printing processes (occupational exposures in)Processed meat (consumption of)Proflavine salts
1333312B32A32A32B33131112A2A31
100C25, Sup 725, Sup 725, Sup 782
Sup 7, 57, 99, 100F808010451, 1161045454
33, Sup 733, Sup 7, 100F19, Sup 7Sup 7, 100A75, 100DSup 7, 49, 100C11945361
61, 100B
201219871987198720022012200220022013In prep.201319921993201019872012198720122012201219762010199119942012
NB: Overall evaluation upgraded to Group 1 with supporting evidence from other relevant data
NB: Evaluated as a group
113110910947
47, 98, 100F201620161920122A312B1332B32B13
35, Sup 7, 92, 100F4547
Sup 7, 100A56107696953, 716565114
24, Sup 7
2010191920121993201619971997199919961996In prep.1987
NB: Overall evaluation upgraded to Group 1 with strong supporting evidence from other relevant data
Agents Classified by the IARC Monographs, Volumes 1–116
CAS No.
ProgestinsProgestogen-only contraceptivesPulp and paper manufacture
Radiofrequency electromagnetic fieldsRadioiodines, including iodine-131
Radionuclides, alpha-particle-emitting, internally deposited
Agent
Group2B2B32B11
VolumeSup 77225, Sup 7102
78, 100D78, 100D
Year198719991987201320122012
NB: Specific radionuclides for which there is sufficient evidence in humans are also listed individually as Group 1 agents
NB: Specific radionuclides for which there is sufficient evidence in humans are also listed individually as Group 1 agents
Additional information
Radionuclides, beta-particle-emitting, internally depositedRed meat (consumption of)Refractory ceramic fibresRock (stone) wool
Rubber manufacturing industry
Salted fish, Chinese-style
Schistosoma haematobium (infection with)
12A2B3111
78, 100D11443, 8143, 8128, Sup 7, 100F56, 100E61, 100B
2012In prep.20022002201220122012
Schistosoma japonicum (infection with)2B611994
Schistosoma mansoni (infection with)Shiftwork that involves circadian disruptionSlag woolSolar radiation32A31619843, 8155, 100D1994201020022012
Soot (as found in occupational exposure of chimney sweeps)1
35, Sup 7, 92, 100F
2012
Special-purpose fibres such as E-glass and '475' glass fibresSulfites
Sunlamps and sunbeds (see Ultraviolet-emitting tanning devices)Surgical implants and other foreign bodies:- Organic polymeric materials (as a group)
- Orthopaedic implants of complex composition- Cardiac pacemakers- Silicone breast implants
- Implanted foreign bodies of metallic chromium or titanium and of cobalt-based, chromium-based and titanium-based alloys, stainless steel and depleted uranium- Dental materials- Ceramic implants
Surgical implants and other foreign bodies:
- Polymeric implants prepared as thin smooth film (with the exception of poly(glycolic acid))
- Metallic implants prepared as thin smooth films
- Implanted foreign bodies of metallic cobalt, metallic nickel and an alloy powder containing 66-67% nickel, 13-16% chromium and 7% ironSV40 polyomavirus Tea
Tetrakis(hydroxymethyl)phosphonium saltsTextile manufacturing industry (work in)Tobacco smoke, second-handTobacco smokingTobacco, smokeless
Toxins derived from certain Fusarium species (see Fusarium)Ultraviolet radiation (wavelengths 100-400 nm, encompassing UVA, UVB, and UVC)Ultraviolet-emitting tanning devicesUrethane (see Ethyl carbamate)
Very hot beverages at above 65 °C (drinking)Welding fumes
Wood dust
Wood smoke (see Biomass fuel, indoor emissions from household combustion)X- and Gamma-Radiation2B3815420021992
3741999
2B741999
3332B111
1045148, 7148
83, 100E83, 100ESup 7, , 100E55, 100D100D11962, 100C75, 100D2013199119991990201220122012
112A2B1120122012In prep.199020122012NB: Volume 100D concluded that there is sufficient evidence for ocular melanoma in welders
Last update 6 July 2016
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