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专利名称：CRF ANALOGS
发明人：RIVIER, Jean, Edouard, Frederic,VALE, Wylie,
Walker, Jr.
申请号：EP907609.5申请日：190620公开号：EP0403591B1公开日：19940914
摘要：we have developed similar to crf (corticotropin releasing factor of) that can beadministered for a significant elevation of acth, beta endorphin, beta lipotropine.otherproducts of the pro opiomelanocortin gene and the levels of corticosterone, and \\/ or alowering of blood pressure over extended periods of time.an analogue which has beenfound to be particularly strong: h - ser glu glu pro pro ile ser leu asp leu thr phe leu leuarg and glu val leu his met ala arg - ala glu gln leu ala gln gln alahis ser asn arg lys leumet glu ile ile - nh2.one of the analogues, one or more of the first five residues may beremoved or termination is replaced by a peptide whose length can be up to 10 aminoacids.and \\/ or an acylation agent containing up to 7 carbon atoms. we can also
proc\éd\ér to a number of other substitutions in the chain.these analogues orsalts thereof in pharmaceuticals and veterinary acceptable carrier, dispersed in a liquid orsolid is acceptable in pharmaceuticals and veterinarycan be administered to mammals,including humans. you can also use this similar incentives to improve mood and memoryand learning.
申请人：THE SALK INSTITUTE FOR BIOLOGICAL STUDIES
代理机构：Lawrence, Malcolm Graham
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